quarta-feira, fevereiro 20, 2019

Paisagens enrugadas

O que acontece à necessidade, quanto á importância de ter uma estratégia e de monitorar as consequências da sua adopção quando se caminha para Mongo?
Mongo significa paisagem cada vez mais enrugada.
"An adaptive landscape is a mapping from a high-dimensional space of genotypes onto fitness or some other related quantitative phenotype, which defines the ‘elevation’ of each coordinate in genotype space. Evolution can be viewed as a hill-climbing process in an adaptive landscape, where populations tend to move towards peaks as a consequence of natural selection.
...
An adaptive landscape that is smooth and single peaked does not pose any obstacle to evolutionary exploration. It is therefore highly navigable, in that it is possible to reach the global peak via positive selection through a series of small mutations that only move ‘uphill’. In contrast, a rugged landscape can block the approach to the highest peak by entrapping populations on local suboptimal peaks.
...
We define landscape navigability as the ability to access a global peak via an evolutionary exploration involving random mutation and natural selection. Landscape navigability is highest when all mutational paths to the global peak exhibit a monotonic increase in binding affinity, which implies a landscape that is smooth and single peaked. Landscape navigability is lowest when no mutational paths to the global peak exhibit a monotonic increase in binding affinity. This implies a rugged landscape with many peaks.
...
The number of peaks in an adaptive landscape is an important indicator of its navigability. The more peaks a landscape has, the less navigable it becomes, if the peaks are of unequal height."
Trechos retirados de "A thousand empirical adaptive landscapes and their navigability" de José Aguilar-Rodríguez, Joshua L. Payne and Andreas Wagner, publicado por Nature Ecology & Evolution 1, 0045 (2017)

Sem comentários: